Go to Preferences > Account settings (double tap the account listed) >  Signature tab to change or add signatures to your outgoing email messages. Signatures are created on a per-account basis, so you can configure each email account with multiple signatures.

Additionally, you can control whether a signature is automatically added to a message (again, on a per-account basis). Just go to Preferences > Accounts > (select an account) then click on 'Composer' tab. Choose whether to add a signature to the message while replying.

You will notice in the above picture that you can also include signatures in Quick Replies.

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